Short-term treatment of Diabetic NOD mice with anti-TNF-α therapy restores immune tolerance to beta cells.

NOD-sp spontaneous new onset diabetic NOD mice;*NOD-sp/stz, a streptozotocin induced diabetic state was induced in NOD recipients. Spontaneously diabetic NOD mice (Groups C, D) were previously restored to a euglycemic state by anti-TNF-α treatment. These mice remained euglycemic 240–300 days following the cessation of treatment.Syngeneic NOD.SCID islet (Groups A, C) or allogeneic C57BL/6 (Groups B, D) islet grafts were transplanted into NOD recipients.