Single cell ATAC sequencing profile of quiescent mesenchymal progenitors

After tissue injury mesenchymal progenitor subsets undergo a transient proliferative expansion, morphological transition and migration from their perivascular niche. Some of these subsets contribute enduring populations to connective tissue structures adjacent to muscle. To gain insights into gene accessibility to complement the single cell RNA seq expression data previously obtained and to uncover the lineage potential of MPs in this context, tdTomato positive cells were profiled by single cell ATAC sequencing. Single cell ATAC-seq analyses of enriched quiescent mesenchymal progenitors from skeletal muscle.