Syntheses of Pyrroles, Pyridines, and Ketonitriles via Catalytic Carbopalladation of Dinitriles

The first example of the Pd-catalyzed addition of organoboron
reagents
to dinitriles, as an efficient means of preparing 2,5-diarylpyrroles
and 2,6-diarylpyridines, has been discussed here. Furthermore, the
highly selective carbopalladation of dinitriles with organoboron reagents
to give long-chain ketonitriles has been developed as well. Based
on the broad scope of substrates, excellent functional group tolerance,
and use of commercially available substrates, the Pd-catalyzed addition
reaction of arylboronic acid and dinitriles is expected to be significant
in future synthetic procedures.