Efficient Preparation of Imidazo[1,5-a]pyridine-1-carboxylic Acids
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http://www.thieme-connect.com/DOI/DOI?10.1055/s-0035-1561489
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资源简介：
We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl)pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-imidazo[1,5-a]pyridin-1-ylethanones were obtained, which were then converted into imidazo[1,5-a]pyridine-1-carboxylic acids in high preparative yields through haloform cleavage.
提供机构：
© Georg Thieme Verlag
创建时间：
2016-07-27
