Re-sequencing of synthetic yeast genome IXR and VIL
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https://www.ncbi.nlm.nih.gov/sra/SRP037705
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资源简介：
Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity: recombinase sites are encoded in a synthetic chromosome, and tightly controlled induction of a modified recombinase creates a population of targeted structural variations. We used this method to scramble large regions of two yeast chromosomes: yeast synthetic chromosome arm synIXR, with 43 recombinase target sites, and synthetic region synVIL, with 5 recombinase sites. Deconvolving the scrambled genomes provides insight into genome structure and function and reveals whether off-target activity or ectopic recombinations interfere with the synthetic design
创建时间：
2015-01-14
