Soft robots with autonomous adaptation for effective drug delivery amidst fibrous encapsulation

The foreign body response impedes the function and longevity of implantable drug delivery devices. As a dense fibrotic capsule forms, integration of the device with the host tissue becomes compromised, ultimately resulting in device seclusion and treatment failure. We present FibroSensing Dynamic Soft Reservoir (FSDSR), an implantable drug delivery device capable of monitoring fibrotic capsule formation and overcoming its consequences via soft robotic actuations. Occlusion of the FSDSR porous membrane was monitored over 7 days in a rodent model using electrochemical impedance spectroscopy. The electrical resistance of the fibrotic capsule correlated to its increase in thickness and volume. Our FibroSensing membrane showed great sensitivity in detecting changes at the abiotic/biotic interface, such as collagen deposition and myofibroblast proliferation. The potential of the FSDSR to overcome fibrous capsule formation and maintain constant drug dosing over time was demonstrated in silico ..., , , # Soft robots with autonomous adaptation for effective drug delivery amidst fibrous encapsulation

The necessary raw data is included and clearly labelled with examples:

**Electrical impedance measurements were taken during animal study data - A1_Left_Device1_Day1_m1 etc.**

A1 - animal

Left - side of the animal device placed

Device1 - device number

Day1 - day measurement taken

m1 - technical replicate

**KNN classfier - *0.3agarose device1 repeat 1*(1) (etc.)**

0.3agarose - concentration of agarose

device1 - device number

repeat 1 - technical replicate

**Comsol model - FSDSR_FCt_75um_Day7_Porosity0.8_Passive_timeS_Cmol_mm (etc.)**

75um - capsule thickness

day7 - day

porosity0.8 - porosity

passive - passive diffusion

TriActN - actuated with a triangular pressure profile followed by number N of actuations over 10 min period

RectActN - actuated with a rectangular pressure profile followed by number N of actuations over 10 min period

timeS - denotes the values in the first...