Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and differentiation, neuronal outgrowth and plasticity. In Alzheimer’s disease (AD), BDNF signaling is known to be i
Loss-of-function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD). The mechanism through which TREM2 contributes to the dis
These are the processed gene expression datasets to accompany the GitHub repo: https://github.com/LewisLabUCSD/AD_secretory_pathway Data originally obtained from 10.1038/s41586-019-1195-2 (Synapse
Aging is a major risk factor for late-onset Alzheimer’s disease (LOAD). How aging contributes to the development of LOAD remains elusive. In this study, we examined multiple large-scale transcriptomic
A pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-Ã protein (AÃ) in the brain. Physical exercise has been shown to reduce AÃ burden in various AD mouse models, but th
