Functional consequences of variants in the SERPINA6/A1 locus significantly associated with morning plasma cortisol in GWAMA, and of the Leuven variant, in CROATIA-Korcula.

aData for total cortisol is from the whole Croatia-Korcula sample, n = 898.bSamples selected for measured free cortisol assay were age and sex matched homozygotes at rs12589136.cadjusted for age, sex, and first three principal components, using kinship matrix derived from GWAS data.Data are geometric mean (95% CI)[n]. Cortisol values are nmol/L, CBG µmol/L, cortisol binding activity nmol/L, and α1-antitrypsin g/L. RCL = reactive centre loop.