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HePulse 885534J3

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DataCite Commons2022-11-01 更新2024-07-13 收录
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HePulse 885534J3 Dataset - A New Design of Precision Silver Doped Diamond-Like Carbon Coating with Superior Bio-Mechanical Performance: Silver (Ag) doped diamond-like carbon (DLC) coatings are in high demand for biomedical applications. However, excess Ag doping in typical Ag/DLC coatings reduces mechanical performance and poses cytotoxicity to human cells. In this work a new Ag/DLC coating model is proposed with precise doping of Ag in a DLC matrix in the form of isolated nanoparticles embedded at controlled depths. The new version of Ag/DLC is designed to perform robust antimicrobial action in the early post-surgery stages, while a confined Ag amount maintains the excellent mechanical and biocompatibility performance of the underlying DLC coating when compared to typical Ag/DLC designs. Pure DLC without Ag, typically made Ag/DLC having 17 at. % Ag doped throughout the DLC matrix and new Ag/DLC coatings with 2 at. % precise Ag doping, are made with a modified magnetron sputtering system with control over the deposition process. The coatings are characterised for structural, mechanical, ion leaching, and cytotoxicity profiles against L929 fibroblast cells. The typical and new Ag/DLC coatings have similar ion release rates of ~ 0.6 ppm and the new design outperforms the typical Ag/DLC with 63% higher hardness, 100% higher Young’s modulus, and 21% higher biocompatibility. This enhanced biomechanical performance of the proposed new Ag/DLC design could have significant potential for coating of load-carrying medical devices.

HePulse 885534J3 数据集——一种具有优异生物力学性能的精准掺杂银类金刚石碳涂层新设计:银(Silver, Ag)掺杂类金刚石碳(Diamond-Like Carbon, DLC)涂层在生物医学领域需求旺盛。但传统银/DLC涂层中过量的银掺杂会降低力学性能,并对人体细胞产生细胞毒性。本研究提出一种新型银/DLC涂层模型,通过将银以孤立纳米颗粒的形式精准掺杂在DLC基体中,并可控其嵌入深度。新型银/DLC涂层旨在在术后早期发挥稳定的抗菌作用,同时通过限制银的掺杂量,相较于传统银/DLC设计,保留了类金刚石碳涂层优异的力学性能与生物相容性。本研究采用改进的磁控溅射系统(magnetron sputtering system),通过调控沉积工艺,制备了纯DLC涂层、传统银掺杂量达17 at.%的均匀掺杂银/DLC涂层,以及银掺杂量仅2 at.%的精准掺杂型银/DLC涂层。随后对涂层的结构、力学性能、离子浸出特性及针对L929成纤维细胞(L929 fibroblast cells)的细胞毒性进行了表征。传统与新型银/DLC涂层的离子释放速率均约为0.6 ppm,而新型涂层的综合性能更优:硬度较传统涂层提升63%,杨氏模量提升100%,生物相容性提升21%。这种经优化的新型银/DLC涂层设计所具备的增强型生物力学性能,在承载式医疗设备的涂层应用中具有重大应用潜力。

提供机构:
Northumbria University
创建时间:
2022-11-01
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