Gene Ontology Annotation Database

The GO Annotation Database (GOA) provides Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB), RNA molecules from RNACentral and protein complexes from the Complex Portal. GOA files contain a mixture of manual annotation supplied by members of the Gene Onotology Consortium and computationally assigned GO terms describing gene products. Annotation type is clearly indicated by associated evidence codes and there are links to the source data.基因本体注释数据库（Gene Ontology Annotation Database, GOA）为UniProt知识库（UniProt Knowledgebase, UniProtKB）中的蛋白质、RNACentral收录的RNA分子以及复合物门户（Complex Portal）中的蛋白质复合物提供基因本体（Gene Ontology, GO）注释。GOA文件中同时混合了基因本体联合会（Gene Ontology Consortium）成员提供的手动注释，以及用于描述基因产物的经计算赋予的GO术语。注释类型可通过关联的证据代码明确标识，且所有条目均附有指向原始源数据的链接。

搜集汇总

背景与挑战

背景概述

GOA数据库为UniProtKB中的蛋白质、RNACentral的RNA分子和Complex Portal的蛋白质复合物提供高质量基因本体（GO）注释。其注释文件结合了手动和计算分配的GO术语，并通过证据代码和源数据链接明确标注类型。