Summary of Temporal MHC studies including population demographic parameters important for generating temporal variation.

‘Fluctuating s’ refers to studies which concluded that fluctuating selection may have increased temporal differentiation of immune genes relative to that of neutral markers. Studies that provided either direct evidence for changes in population size, or temporally unstable population structure, were considered to have a fluctuating census population size (‘Fluctuating Nc’). ‘Populations’ indicates the number of sampled populations and ‘Alleles’ indicates the total observed number of MHC alleles in the sampled metapopulation.