Proteomics raw data of feline mammary tumors
收藏Mendeley Data2026-04-09 收录
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资源简介：
Distinct proteomic signatures with specific protein expression patterns data were identified in formalin-fixed, paraffin-embedded (FFPE) feline mammary carcinoma cribiform and tubulopapillary samples using mass-spectrometry-based analysis and compared with human breast cancer proteomic data obtained from Human Protein Atlas. We hypothesized that specific proteins are responsible for the mechanisms of disease progression in cribiform and tubulopapillary and that similar prognostic markers may be identifiable in both feline mammary carcinoma and human breast cancer tissues. The FFPE samples (10 X 10 µm) were deparaffinized and rehydrated in sequential, decreasing concentration ethanol baths, followed by protein extraction, quantification, in-gel tryptic digestion, and mass spectrometry to identify the protein. Four proteins each were specific for cribiform and tubulopapillary feline mammary carcinoma, while 2 proteins, indicative of poor prognosis, similar to human breast cancer were identified in both feline groups.
提供机构：
Universidade Estadual da Londrina Hospital Universitario da UEL; Universidade Estadual Paulista Julio de Mesquita Filho Faculdade de Medicina Veterinaria e Zootecnia Campus de Botucatu; Universidade Estadual Paulista Julio de Mesquita Filho
