CD86

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

本基因编码一种I型膜蛋白，属于免疫球蛋白超家族成员。该蛋白由抗原呈递细胞表达，是T细胞细胞表面的CD28抗原和细胞毒性T淋巴细胞相关蛋白4的配体。该蛋白与CD28抗原的结合是T细胞激活的共刺激信号。该蛋白与细胞毒性T淋巴细胞相关蛋白4的结合则负向调节T细胞激活，并减弱免疫反应。选择性剪接导致产生多种转录变体，这些变体编码不同的同源异构体。[由RefSeq提供，2011年5月]