WT MSCs displayed a different transcriptional profile than KO MSCs.
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE217089
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To explore the molecular basis of the therapeutic function of MSCs, we performed RNA-sequencing of LPS-treated MSCs.Transcriptome analysis identified the upregulation of 673 genes and downregulation of 831 genes, and plot the top 100 differentially expressed genes into a heatmap.KEGG pathway enrichment analysis indicated that energy metabolism pathways were highly enriched in the cell cycle. WT and KO MSCs were stimulated with/without 3 μg/mL LPS for 24 h.Total RNA was extracted and purified using TRIzol reagent (Invitrogen, USA) according to the manufacturer’s protocol.The library was sequenced with Illumina Novaseq™ 6000 by 2×150bp paired-end sequencing (PE150) (LC-Bio Technology CO., Ltd., Hangzhou, China) following the vendor's recommended protocol. T
创建时间：
2024-11-06
