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资源简介：
APE1 knock-in
应用场景：
创建时间：
2011-10-01
相关数据集
'构建基因编辑工具鼠，并用已知功能的致死基因验证体内基因敲除的有效性'的相关数据集
CRISPR-stop技术将蛋白质编码序列转化为终止密码子，从而在适当的位置产生了无效等位基因。CRISPR-stop在单细胞期合子中诱导产生Founder 0（F0）纯合突变体小鼠，这避免了小鼠繁殖并可作为非致命基因的快速筛选方法。然而哺乳动物25%的基因，其功能丧失会导致早期死亡。在这里，我们在二细胞期合子中的一个细胞进行CRISPR-stop操作，一种我们称之为嵌合型CRISPR-stop的
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Methods for plant transformation
The methods disclosed herein use a morphogenic gene or a repressor gene to provide a transgenic plant containing a single copy of a transgenic event wherein the morphogenic gene or the repressor gene
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Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair
Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that
NIAID Data Ecosystem40
Transposon screen mappings
piggyBac vector integration sites in mouse embryonic stem cells. Mapped to mouse genome m38. Fields (tab separated:ChromosomeStrandPositionTotal reads mapping to this positionReads for this barcodeBar
DataCite Commons2020-09-04 更新80
gene editing in rice by CRISPR/Cpf1
To demonstrate Cpf1 can be engineered to modify PAM recognition, broadening the targeting range in rice.
NIAID Data Ecosystem50
