Conditional associations for BRCA1 and BRCA2 top SNPs.

The table shows the HR estimate. 95% CI and p-value for the conditional analysis adjusting for the lead SNP in the univariate analysis for BRCA1 (left hand side) or BRCA2 mutation carriers (right had side). SNPs correspond to: rs10124837, the strongest associated in BRCA1; rs62543583, the strongest associated in BRCA2 mutation carriers; rs7046326, the strongest associated in BRCA1/2 meta-analysis; rs3814113, was the strongest associated variant in the initial GWAS analysis. “HR”, hazard ratio; “CI”, confidence interval.

本表格展示了针对BRCA1（左侧）或BRCA2突变携带者（右侧）的单因素分析中调整主导SNP的条件下，HR估计值、95%置信区间和p值。SNPs分别对应：rs10124837，与BRCA1最强烈的关联；rs62543583，与BRCA2突变携带者最强烈的关联；rs7046326，与BRCA1/2荟萃分析最强烈的关联；rs3814113，是初始GWAS分析中最强烈的关联变异体。“HR”，表示风险比；“CI”，表示置信区间。