Biomimetic Semisynthesis of Arglabin from Parthenolide
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https://figshare.com/articles/dataset/Biomimetic_Semisynthesis_of_Arglabin_from_Parthenolide/2495296
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资源简介:
The semisynthesis of arglabin, an anticancer drug in
clinical application,
is developed from abundant natural product parthenolide via three
steps. Each step in this sequence is highly stereoselective, and the
substrate-dependent stereoselectivity in the epoxidation step can
be explained by computational calculations. The success of chemical
semisynthesis of arglabin suggests that the biosynthesis of arglabin
might proceed in a similar pathway.
创建时间:
2012-08-17



