IL27

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

该基因编码的蛋白质是该异二聚型细胞因子复合物的亚基之一。该蛋白质与白细胞介素12A (IL12A) 相关。它能与爱泼斯坦-巴尔病毒诱导基因3 (EBI3) 相互作用，EBI3 蛋白与白细胞介素12B (IL12B) 类似，并形成一种复合体，该复合体已被证明能够促进未成熟的而非记忆型 CD4(+) T 细胞的迅速增殖。该复合体还发现与白细胞介素12协同作用强烈，以触发未成熟型 CD4(+) T 细胞的干扰素伽马 (IFNG) 生成。该细胞因子的生物学效应是通过 I 类细胞因子受体 (WSX1/TCRR) 介导的。[参考资料：RefSeq，2008年7月]