Transcriptome dataset of human corneal endothelium derived from patients with Fuchs endothelial corneal dystrophy

Fuchs endothelial corneal dystrophy (FECD) is the most common inherited corneal disease. Fibrillar focal excrescences called guttae and corneal edema due to corneal endothelial cell death result in progressive vision loss. Multiple genetic variants for FECD have been reported, but the pathogenesis is not fully understood. Our goal in the current study was to obtain an RNA-Seq dataset of corneal endothelial cells derived from Caucasian FECD subjects to identify differentially expressed genes and conduct enrichment analysis to reveal pathways that are potentially related to the pathophysiology of FECD.