Dependence of Molecular Properties on Proteomic Family for Marketed Oral Drugs

An association of drugs with their proteomic family reveals
that molecular properties of drugs targeting proteases, lipid and peptide
G-protein-coupled receptors (GPCRs), and nuclear hormone receptors
significantly exceed limits for some properties in the “rule of five”,
while drugs targeting cytochrome P450s, biogenic amine GPCRs, and
transporters have significantly lower values for certain properties. Also,
the variation in drug targets appears to be a factor explaining increasing
molecular weight over time.