Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.

Data from ProteomeXchange, PXD ID: PXD001101. Experiment: pST_SILAC_R1a, file: H3255_pST_SILAC_R1_F4_a.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):340-55 . From the Abstract: {{i}} . We sought to identify the immediate direct and indirect phosphorylation targets of mutant EGFRs in lung adenocarcinoma. We undertook SILAC strategy, phosphopeptide enrichment, and quantitative MS to identify dynamic changes of phosphorylation downstream of mutant EGFRs in lung adenocarcinoma cells harboring EGFR(L858R) and EGFR(L858R/T790M) , the TKI-sensitive, and TKI-resistant mutations, respectively. {{/i}}