RNA sequencing of mouse liver and kidney after 1-month treatment with predicted longevity compounds

This dataset consists of liver and kidney gene expression profiles of young UM-HET3 mice subjected to the following compounds for 1 month: AS-703026 (liver and kidney), enzastaurin (liver and kidney), GDC-0941 (liver and kidney), ascorbyl-palmitate (kidney), AZD8055 (kidney) and KU0063794 (kidney). Corresponding age-, sex- and strain-matched littermate controls for kidney are also presented. This dataset complements liver RNAseq profiles of control UM-HET3 mice and mice subjected to ascorbyl-palmitate, AZD8055 and KU0063794 (collected and sequenced at the same time) stored at GSE131868. Overall design: 3-month old UM-HET3 male mice from University of Michigan Medical School were subjected to GDC-0941 (50 ppm), enzastaurin (75 ppm), AS-703026 (30 ppm), KU0063794 (10 ppm), AZD8055 (20 ppm) and ascorbyl-palmitate (6.3 ppm) for 1 month. Their littermate controls of the same age and sex were also used for the analysis. 4 biological replicates were used for the each compound, and 6 biological replicates were used for the control group. In all cases, interventions continued until the animals were sacrificed.