Primary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Bulk RNAseq. Primary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Bulk RNAseq
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJEB76194
下载链接
链接失效反馈官方服务：
资源简介：
Several fusion oncogenes showing a higher incidence in pediatric acute myeloid leukemia are associated with heterogeneous megakaryoblastic and other myeloid features. Here we addressed how developmental mechanisms influence human leukemogenesis by ETO2::GLIS2, a hallmark of dismal prognosis. We induced expression of ETO2::GLIS2 in primary human fetal and cord blood CD34+ hematopoietic cells and obtained bulk transcriptomes after in vitro cultures or in vivo engraftment and leukemia development in immunodeficient recipients (NSG or NSG-SGM3=NSG-S).
创建时间：
2024-10-09
