Atractylenolide 1 targets FLT3 to regulate PI3K to inhibit osteogenic differentiation of human valve interstitial cells

Atractylenolide 1, a natural active ingredient extracted from Atractylodes macrocephala, has been proved to have good anti-inflammatory and anti fibrosis effects. Osteogenic changes induced by inflammation of valve interstitial cells plays a key role in the development of calcified aortic valve disease.This study aimed to investigate the anti osteogenic differentiation of AT1 in human valve interstitial cells.