Transcriptome analysis identifies the dysregulation of ultraviolet target genes in human skin cancers

In this study, we performed RNA-Seq studies to generate a transcriptomic cohort containing UV-responsive genes in human skin cells exposed to different UVR conditions. We then performed rigorous bioinformatics analysis to define a UV gene expression signature that is conserved among cells from different donors. We further demonstrated that the UV signature genes are significantly enriched in genes dysregulated in human skin squamous cell carcinomas. Overall design: UV-responsive genes were identified by characterzing the differentially expressed genes between UV-irradiated human keratinocytes and non-irradiated control keratinocytes.