Epigenetic Signatures of Brain Aging by Single Nucleus Methylation Sequencing [FC-9mo-m]

Illustrating aging effects on the epigenomic features of brain is critical to understand brain functional decline and neurodegeneration. Single nucleus methylation sequencing was applied to brain regions of both male and female mouse at the age of 2, 9 and 18 months. We use these data to identify the epigenomic changes with aging in mouse brains. Overall design: Apply snmC-seq3 to mouse brain regions to identify aging effects on epigenomics Processed data for these samples are available at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313770