Additional file 4: Table S3. of Identification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screening

First 1 000 most depleted genes for HCC-827 cell lines. This table shows the list of 1 000 most depleted genes in the HCC-827 cells along with their sgRNA fold changes at the days 14, 21 and 28. Gene expression of target genes is indicated as average FPKMs across 3 replicates. Cumulative scores are calculated as the sum of log2 FC scores obtained at either two or all three time points. Genes are ranked by the cumulative score obtained at all three time points (e.g. as the sum of log FC scores at days 14, 21 and 28 sorted in ascending order). Essential genes identified in recent genetic screens are reported. Genes expressed at low levels in the parental cell line (FPKM < 1) are highlighted in grey. (XLSX 127 kb)