Effect of depletion of MDMX (aka MDM4) on gene expression in uveal melanoma cell line MEL202

To investigate the effect of MDMX depletion on the transcriptome of MEL202 cells we established 5 derivatives either containing a doxycyline- inducible Contrl shRNA or with 4 distinct MDMX -targeting shRNAs In thee biological replicates the cells were treated with doxycycline for 48 hrs after which RNA was isolated Overall design: Comparative gene expression profiling analysis of RNA-seq data for MEL202/i-shCtrl compared to MEL202/i-shMDMX).