Base editing in Danio rerio. Danio rerio

NIAID Data Ecosystem2026-03-13 收录

斑马鱼疾病建模

碱基编辑技术

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA825759 数据链接链接失效反馈

官方服务：

资源简介：

Disease modeling by efficient genome editing using a near PAM-less base editor in zebrafish

创建时间：

2022-04-12

De Novo Structural Mining and Engineering of New TadA Deaminases for Highly Efficient Adenine Base Editors

碱基编辑技术

蛋白质工程

Protein function is primarily determined by tertiary structure, yet enzyme discovery has relied heavily on sequence homology. Here, we present a structure-guided mining framework integrating AlphaFold

NIAID Data Ecosystem320

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

碱基编辑技术

疾病动物模型

Base editor (BE) systems convert C-to-T in vitro and in vivo1-4. However, forty eight percent of genetic diseases involve C-to-T substitution, and modeling or correcting such diseases requires the ade

NIAID Data Ecosystem150

The CRISPR-based C-to-T base editing system. Danio rerio

碱基编辑技术

斑马鱼遗传

The codon-optimized zAncBE4max construct contains the Uracil glycosylase inhibitor(UGI) and Deaminase (rAPOBEC1)-coupled Cas9a D10A nicknase, and NLS to enabe C-to-T base editing in the whole genome o

NIAID Data Ecosystem60

Harnessing Self-Labeling Enzymes for Selective and Concurrent A-to-I and C-to-U RNA Base Editing

碱基编辑技术

基因编辑脱靶评估

The SNAP-ADAR tool enables precise and efficient A-to-I RNA editing in a guideRNA-dependent manner by applying the self-labeling SNAP-tag enzyme to generate RNA-guided editases in cell culture. Here

NIAID Data Ecosystem150

ABE for Liver

碱基编辑技术

肝脏基因纠正

These are the next-generation sequencing files associated with publication evaluating genetic correction.

NIAID Data Ecosystem70