five

Clonal hematopoiesis quantified in human bone marrow whole genome sequencing data

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This repository contains somatic variant calls and pre-processed data accompanying the manuscript Detecting and quantifying clonal selection in somatic stem cells Verena Körber1,2*, Niels Asger Jakobsen2, Naser Ansari-Pour2,3, Rachel Moore2,4, Nina Claudino1, Marlen Metzner2, Eva Thielecke1,2, Franziska Hörsch1, Batchimeg Usukhbayar2, Mirian Angulo Salazar2, Simon Newman3,5, Benjamin JL Kendrick3,5, Adrian H Taylor3,5, Rasheed Afinowi-Luitz5, Roger Gundle3,5, Bridget Watkins3, Kim Wheway3, Debra Beazley3, Stephanie G Dakin3, Antony Palmer3,5, Andrew J Carr3, Paresh Vyas2*† Thomas Höfer1*† Affiliations: 1 Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ); Heidelberg, Germany. 2 MRC Molecular Haematology Unit, Oxford Biomedical Research Center, Hematology Theme, Oxford Centre for Haematology, Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford; Oxford UK. 3 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford; Oxford UK. 4 Cambridge Genomics Laboratory, Cambridge University Hospitals, Cambridge, UK; 5Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust; Oxford UK. †These authors contributed equally. *Correspondence: verena.korber@ndcls.ox.ac.uk (VK), paresh.vyas@imm.ox.ac.uk (PV), t.hoefer@dkfz.de (TH)
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2025-01-10
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