Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction: Supplementary data

Aim: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related
genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. Materials & methods: Four
gene enrichment analyses defined DE-FRGs’ biological functions and pathways. Three strategies were
applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune
cell infiltration, drugs, and ceRNA was explored. Results: DE-FRGs were enriched in lipid metabolism. A
risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for
DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes.
Thirty-five drugs are candidate therapeutic targets. Conclusion: A nomogram and new biological targets
for early diagnosis and treatment of DCM and myocardial infarction were provided.
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