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Published Orthogonal Replication, Exact Response Algebra, Strict Same-Core Falsification Protocol, and Exhaustive Assay Scorecard of a Native Fracture-State Family in a Computational Longevity Discovery Pipeline (Trinity Claims #87-#120, 2026-03-26)

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Zenodo2026-03-27 更新2026-05-26 收录
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This version fixes the next mechanistic and experimental milestone from the Trinity computational longevity-discovery pipeline. Claims #87-#120 establish an exact operational plateau for native fracture-state admission, orthogonal replication of the target TOP3A/RMI2/CCDC69 family in published huMAP3 layers, selectivity and explicit taxonomy of the analyzable published split-family background, strong-core switch decomposition, an arm-polarized fracture axis, flat-to-polarized amplification, cryptic stable hierarchy, top-arm conservation, dual-collapse taxonomy, permutation rigidity, exact three-term response algebra, a dominant-dual falsification simplex, a strict same-core falsification protocol, and a final phase-85 assay scorecard in which every analyzable published family lands in one exact experimental outcome region. The observed scorecard regions are pass = 1, ceiling_residue = 4, symmetric_dual = 1, and null_repair = 1, with bridge_first_inversion and diffuse_control_leak preregistered but unoccupied in the current published background. The target TOP3A/RMI2/CCDC69 family is the unique all-pass positive-margin state, with score code 1111 and minimum acceptance slack 0.048158. This package contains the milestone report, claim documents, phase reports, scorecard tables, source files, the fracture-aware generator source, and the wet-lab/falsification materials needed to score the first same-core experiment without post hoc reinterpretation. This is a computational discovery and preregistration package and not a completed causal validation study.

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2026-03-27
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