Computational simulations show proof-of-concept for optogenetic suppression of ectopic activity in cardiac stem cell therapy

This dataset contains data required to reproduce computational simulations presented in the 2025 paper by Yang et al. This data set comprises (1) Geometric descriptions of the simulation domain (whole heart, tissue wedge, etc.), with point clouds interconnected by finite elements, each of which is associated with a vector encoding local myofiber orientation. (2) Parameter files describing functional cell- and tissue-scale properties of different tissue regions, perturbations to be applied to the model during the simulation (e.g., electrical stimuli), and numerical solver settings. (3) Initial condition state files describing the functional state of the model at the beginning of the simulation, if these conditions differ from the cell-scale default parameters. All of the above are stored in plain text or binary formats compatible with the openCARP framework, which is freely available for non-commercial use., , # Computational simulations show proof-of-concept for optogenetic suppression of ectopic activity in cardiac stem cell therapy

This dataset contains data required to reproduce computational simulations presented in the 2025 CVET paper by Yang et al (DOI: 10.1007/s13239-025-00794-x)

Please contact Dr. Patrick M. Boyle ([[e-mail]](mailto:[e-mail])) with any questions, concerns, complaints, or difficulties.

#### **Description of the data and file structure**

Raw data for Figures 3,5 and 6 can be found in Raw_Figure_Data_V2.xlsx. This can be opened in Microsoft Excel.

Figure 3 sheet contains raw values of spontaneous beating frequency of the cell-scale hPSC-CM for the different irradiances and opsins tested.

Figure 5 sheet contains the percentage of simulations where GHE was observed when different irradiances were applied for the three geometries.

Figure 6 sheet contains the minimum, first quartile (Q1), median (Q2), third quartile (Q3), and maximum for values calculat...,