Histone H3.3K27M mutation activates multiple cancer/testis antigens
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE102886
下载链接
链接失效反馈官方服务：
资源简介：
Lysine27Methionine mutations (K27M) in the histone H3 (H3.3 and H3.1) are highly prevalent in pediatric high-grade gliomas (HGG). This study found H3.3K27M caused the upregulation of multiple cancer/testis (CT) antigens, include IL13RA2 and VCX family proteins. Overexpression of VCX3A/B stimulates the expression of genes involved in immune response. Total RNA was extracted from Res259 cells stably expressing H3.3K27M, pCMV6-Entry (empty vector), different forms of GFP-VCX3A/B, or GFP (as control), and subjected to an Illumina HT12.2 Bead CHIP array analysis.
创建时间：
2021-07-25
