Pd-Catalyzed Diastereoselective Trifluoromethylthiolation of Functionalized Acrylamides
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https://figshare.com/articles/dataset/Pd-Catalyzed_Diastereoselective_Trifluoromethylthiolation_of_Functionalized_Acrylamides/5417572
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资源简介：
The Pd-catalyzed
diastereoselective trifluoromethylthiolation of
acrylamides was developed to allow the formation of the Z-isomer as a single product. Using a C–H bond functionalization
strategy, the method was applied to a broad range of α-aryl,
α-alkyl, and α,β-disubstituted acrylamides bearing
the amide derived from the 8-aminoquinoline as a directing group.
Mechanistic studies as well as postfunctionalization of the products
were performed. This approach opens new routes to unprecedented SCF3-containing scaffolds.
创建时间：
2017-09-18
