Enantioselective Syntheses of Morpholines and Their Homologues via S<sub>N</sub>2-Type Ring Opening of Aziridines and Azetidines with Haloalcohols
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A highly regio- and stereoselective strategy for the syntheses in high yield and enantioselectivity of a variety of substituted nonracemic morpholines and their homologues is described. The reaction proceeds via an SN2-type ring opening of activated aziridines and azetidines by suitable halogenated alcohols in the presence of Lewis acid followed by base-mediated intramolecular ring closure of the resulting haloalkoxy amine.
创建时间：
2009-09-18
