Dual T cell– and B cell–intrinsic deficiency in humans [CD4+ T cell SubSeries]

Human RLTPR deficiency is a combined immunodeficiency affecting the CD28-responsive pathway in T cells and the BCR-responsive pathway in B cells. This SubSeries contains high throughput gene expression data from primary CD4+ T cells of patients with RLTPR deficiency and controls. Primary CD4+ T cells from three patients and 4 unrelated controls were stimulated for two hours with PMA, CD40L or IgM.