Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Knockout Mice

Hepatocellular carcinoma (HCC) is the fourth most common cancer worldwide and is associated with a poor prognosis. We performed NGS-based transcriptome analysis between WT and KO liver tumour tissues to understand deletion of ChREBP delays insulin-induced hepatocarcinogenesis, which suggests a combined oncogenic and lipogenic function of ChREBP along AKT/mTOR-mediated proliferation of hepatocytes and induction of hepatocellular carcinoma.