DEDuCT

Humans are being exposed to myriad chemicals in their daily environment including those contained in consumer goods, food, pharmaceuticals, and household products. Most of these daily use products were introduced or developed for human benefit, however, exposure to a minority of chemicals in these products can cause deleterious effects through serious damage to several organ systems. One such group of chemicals, namely, Endocrine Disrupting Chemicals (EDCs), have the ability to perturb the normal functioning of the biological system. In order to screen such chemicals in our daily life, we have developed a detailed workflow which was employed to process more than 16000 scientific abstracts to identify EDCs with supporting evidence for endocrine disruption upon exposure based on the observed endocrine-mediated endpoints specific to humans or rodents. Using our workflow, we identified 686 potential EDCs with supporting evidence of systems-level endocrine-mediated endpoints in published literature spanning 1796 research articles specific to humans or rodents