Model destription: The model describes the dynamics of murine IRF7 gene expression upon IFN stimulation. The present model comprises known key components and feedback mechanisms. The overall system
(A) Values used for the PU.1–GATA-1 network in Equation 3. (B) Values of the additional parameters used for the PU.1–GATA-1 network including the gene X in Equation 4. For Figure 2A, , and for Figure
Probabilities were calculated using a Monte Carlo algorithm with 1000 runs in GINsim. E1 represents GoF and KO represents LoF of the corresponding element of the circuit.
