Developing a Clinically Translatable iPSC-derived Immunotherapy

Stem cell-derived immunotherapies represent immense promise for patients with aggressive cancer. This thesis has designed clinically translatable methods to generate billions of gene-edited blood cells with improved ability to recognise and eliminate ovarian cancer. The results provide the foundation for future development of widely compatible, cost-effective, ‘off-the-shelf’ cellular therapies for patients diagnosed with cancer.