Transcriptomic analysis of THAP1 mediated oligodendrocyte development

We demonstrated previously that THAP1 plays a cell-autonomous role in regulating myelination during early postnatal CNS development (Yellajoshyula et al., Dev Cell, 42, 52-67, 2017). To begin to examine the mechanisms responsible for this role, we performed RNAseq at multiple time points on cultured control (Thap1+/+) and Thap1 null (derived from Thap1flx/-; Olig2-Cre+) OPC under differentiating conditions. RNA-Seq analysis for 3 individual clones of Control and Thap1 null OPC differentiated for days 0, 2 & 4.