Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions

This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular junction (NMJ) function in skeletal muscle tissue. The study compared vehicle-treated versus BAY2416964-treated aged mice, revealing key differentially expressed proteins involved in axonal development and NMJ stability.