Supporting figures and tables.

Figure S1, One polymorphic site is removed at a time from all the genotypic sets in the population to predict the probable risk allele. The effect is studied in terms of the number of unique cases with precancer (leukoplakia) and cancer remaining after each locus deletion. The number under each bar in the X axis represents the omitted locus. A) Exclusion of SNP2 shows highest decline in the size of population suffering from cancer. B) Deletion of any locus is not associated with increase or decrease in precancerous population. C) Exclusion of SNP4 shows highest decline in the size of healthy (control) population. Figure S2, Restructuring of the case-control specific genotypes as different supersets are created taking 4 SNPs at a given time, the one removed each time is denoted by "*". Figure S3, One SNP at a time is removed from all the genotypic set in the ACS-control population to observe the effect after omission of one locus. The removed locus is denoted by * in the genotype supersets taking 4 loci at a time. The effect is studied in terms of the distribution of population under different conditions namely Case, Control and Common groups. Table S1, Polymorphisms identified in P2RY1 and P2RY12 genes. Table S2, A. Frequency of combination of genotypes among ACS patients, respective controls and combined individuals. B. Frequency of combination of genotypes among oral cancer patients, precancer patients and controls. Table S3, p values after omission of one SNP from oral cancer and control population. Omission of SNP2 and SNP4 significantly decrease the case specific and control specific genotypic fraction respectively. Therefore SNP2 might be called as ‘risk SNP’ and SNP4 as ‘protective SNP’. The significant p-values are marked as ‘*’. Table S4, A. Frequency of combination of genotypes obtained after omission of one SNP from ACS and control population B. Frequency of combination of genotypes obtained after omission of one SNP from oral cancer, leukoplakia and control population. Omitted SNPs are marked as ‘*’.
(DOC)