Extracellular vesicles from prostate tumors reshape the pre-metastatic bone environment in an mTOR/RAB1A-dependent manner

Herein, we discover that inhibiting the mTOR/RAB1A axis suppresses EV secretion, thereby inhibiting the formation of the pre-metastatic immunosuppressive microenvironment. Our results further support that tEVs disrupt normal bone marrow cell development and induce an imbalance between B lymphocytes and myeloid cells, indicating that RAB1A may serve as a novel therapeutic target for PCa treatment.