Whole-genome sequences of 211 actinomycete strains from diverse environments: A resource for biosynthetic potential exploration

Actinomycetes represent a highly diverse microbial group that plays a pivotal role in the development of antibiotics and other bioactive secondary metabolites. Recent advances in genome mining technologies have unveiled numerous biosynthetic gene clusters (BGCs) in actinomycete genomes that remain unactivated, highlighting their untapped potential for bioactivity. To explore this potential, we employed high-throughput sequencing to generate high-quality genome sequences for 211 actinomycete strains isolated from diverse environmental samples. These assembled genomes demonstrated excellent completeness and accuracy. Genome analysis predicted a total of 5,348 BGCs, including many clusters associated with unknown products. We anticipate that the public sharing of these genome data will provide a valuable resource for the comprehensive evaluation of actinomycetes' metabolic potential, thereby accelerating the discovery of novel antimicrobial agents.