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Whole genome sequences of mouse embryonic fibroblasts. Mus musculus

NIAID Data Ecosystem2026-03-13 收录

辐射遗传学

基因组稳定性

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https://www.ncbi.nlm.nih.gov/bioproject/PRJDB11291 数据链接链接失效反馈

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investigate the effects of irradiation on genomic alterations, we analyzed whole-genome sequences of immortalized Arf+/- MEFs and mismatch repair (MMR)-deficient Msh2-/- MEFs, and compared 1 Gy-irradiated and non-irradiated backgrounds; MEFs in primary growth (P3) were used as controls.

应用场景：

创建时间：

2022-07-05

基因组稳定性

染色质结构

Endogenous retroviruses (ERVs) have provided an evolutionary advantage in the diversification of transcript regulation and are thought to be involved in the establishment of extraembryonic tissues dur

干细胞与再生医学数据中心2022-02-20 更新70

Regulator of Ty1 transposition protein 105 (Rtt105) is an RPA chaperone and is required for genome stability maintenance

分子生物学

基因组稳定性

Single-stranded DNA (ssDNA) binding protein Replication Protein A (RPA) is essential for protecting ssDNA at replication forks. However, how RPA is guided to DNA replication forks remains unclear. Her

NIAID Data Ecosystem50

Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Primary screening for 1mGyA familly).. Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Primary screening for 1mGyA familly).

辐射遗传学

基因组拷贝数变异

Transgenerational effects of continuous low dose-rate (LDR) gamma-ray irradiation have not been well studied. Recent advances in DNA technology enabled us to examine a whole genome at molecular level.

NIAID Data Ecosystem50

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity

基因组稳定性

DNA修复

Fanconi anemia (FA) is characterized by bone marrow failure, congenital abnormalities, and cancer predisposition. Mutations in RAD51 paralogs have been identified in FA-like disorders and cancers. Alt

DataONE2026-01-08 更新60

Numbers of unselected UV-induced LOH events, deletions/duplications, and chromosome number changes in sectored colonies derived from UV-treated wild-type, rad14 , mus81 , and yen1 diploids. 1

基因组稳定性

DNA损伤修复

1For all strains, we examined unselected LOH events and other genomic changes in sectored colonies resulting from crossovers on chromosome V. 2We operationally define a BIR event as a terminal LOH eve

NIAID Data Ecosystem50

Whole genome sequences of mouse embryonic fibroblasts. Mus musculus

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