HLA Class II Allele Prevalence in the Initial IPF Cohort.

HLA allele prevalences (the percentages of subjects with one or more copies of the allele) in the initial U. Pgh. IPF transplant recipient population (n = 79) were compared to those of a normal reference population (n = 196). DRB1*15 was the most over-represented of the common HLA Class II alleles among the IPF (bold) relative to the controls. These initial findings prompted further study by recruitments of IPF validation cohorts from four other medical centers and high resolution typing of the DRB1*15 allele (see text).