Amplicon-based bisulfite sequencing of promoter regions for selected tumour supressor genes in DNA from white blood cells.

We report the higher sensitivity of NGS-based methylation analysis compared to the array-based techniques for the detection of low-frequency, mosaic, monoallelic methylation. This study describes a computational framework for the analysis of methylation sequencing data. DNA methylation analysis in male white blood cell samples using bisulfite sequencing and tiling array.