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Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming

ChEBI2015-05-05 更新2026-07-21 收录

线粒体功能障碍

癌细胞重编程

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-68525 数据链接链接失效反馈

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Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming

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2015-05-05

癌细胞重编程

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Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

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Additional file 6 of m6A-dependent glycolysis enhances colorectal cancer progression

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Additional file 6 Table S4. m6A-seq analysis in HCT116 WT and METTL3-knockout cells.

Figshare2020-04-04 更新30

RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1 [ChIP-Seq]

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Background: Hepatocellular carcinoma (HCC) cells undergo reprogramming of glucose metabolism to support uncontrolled proliferation, of which the intrinsic mechanism still merits further investigation.

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A Glutathione S‑Transferase Pi Molecular Glue Tethers Splicing Factors and Remodels Cell Metabolism

分子胶机制

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Here, we discovered a tyrosine-reactive GSTP1 inhibitor can function as a molecular glue via a ligand induced protein tethering (LIPT) mechanism. Electrophilic modification of GSTP1 results in disulfi

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Premature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]

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We report a reprogrammable mouse system in which reprogramming factor expression in vivo can be controlled temporally by treatment with doxycycline (Dox). Transient expression of reprogramming factor

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Disruption of Cytochrome c Oxidase Function Induces Warburg Effect and Metabolic Reprogramming

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